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Functional and Magnetic Resonance Imaging Correlates of Callosal Involvement in Multiple Sclerosis Arch Neurol 50:1077-1082, Pelletier,J.,et al, 1993 See this aricle in Pubmed Article Abstract Interhemispheric transfer and/or integration was impaired in patients with MS for all modalities explored and proportional to both degree of callosal atrophy and diffusion of white-matter lesions.Moreover,in good agreement with data obtained from partial comissuratomy studies,performance on each functional task was predominantly associated with atrophy of one part of the callosum,namely left-ear dichotic suppression with the posterior callosal region,alternate finger tapping with the anterior region,and cross-localization with midanterior and posterior regions.Finally,a subgroup of patients without MRI white-matter hyperintensities also showed significant impairment of callosal function and relative atrophy of the callosum.These findings suggest the potential clinical value of callosal involvement in MS and the usefulness of MS as a model of interhemispheric disconnection.

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(click to filter results - removes previous filter) corpus callosum corpus callosum,atrophy of corpus callosum,lesion of dichotic hearing disconnection syndrome MRI MRI,abnormal multiple sclerosis

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